Alterations in mitochondrial function and cytosolic calcium induced by hyperglycemia are restored by mitochondrial transcription factor A in cardiomyocytes

metabolic syndrome and mitochondrial transcription factor a

Mitochondrial and cytosolic calcium dynamics are differentially regulated in plants.

The role of mitochondrial calcium in plant cell signaling has received little attention due to the technical difficulties in measuring changes in the mitochondrial free calcium concentration ([Ca ]m) in vivo. Here, we describe the unprecedented use of targeted aequorin to produce stably transformed Arabidopsis plants that both enable the analysis of mitochondrial calcium dynamics in planta and ...

Cortisone-induced Alterations in Mitochondrial Function

The effects of cortisone treatment on oxygen consumption, oxidative phosphorylation, and fine structure of rat liver mitochondria have been studied. Male rats weighing 125 g were treated for 6 days with 5 mg of cortisone acetate or isotonic saline. On the 7th day, sections of liver were excised and processed for light and electron microscopy. Mitochondrial respiration and oxidative phosphorylat...

Overexpression of Mitochondrial Genes (Mitochondrial Transcription Factor A and Cytochrome c Oxidase Subunit 1) in Mouse Metaphase II Oocytes following Vitrification via Cryotop

Background: Gamete cryopreservation is an inseparable part of assisted reproductive technology, and vitrification is an effective approach to the cryopreservation of oocytes. The aim of this study was to investigate vitrification effects on the expression levels of mitochondrial transcription factor A (Tfam) and mitochondrial-encoded cytochrome c oxidase subunit 1 (Cox1) in mouse metaphase II o...

Yeast mitochondrial RNAP conformational changes are regulated by interactions with the mitochondrial transcription factor

Mitochondrial RNA polymerases (MtRNAPs) are members of the single-subunit RNAP family, the most well-characterized member being the RNAP from T7 bacteriophage. MtRNAPs are, however, functionally distinct in that they depend on one or more transcription factors to recognize and open the promoter and initiate transcription, while the phage RNAPs are capable of performing these tasks alone. Since ...